►个人简介
122cc太阳集成游戏副教授
地址:青岛市郑州路53号青岛科技大学四方校区CCF大楼1113室
研究生招生:1077药学,0860生物与医药
工作邮箱:zhangcl@qust.edu.cn电话(微信):15253260911
2015年获中国农业大学应用化学系理学博士学位,2015年07月至2017年09月于中国海洋大学医药学院开展药物化学方向博士后研究,2017年10月至2020年09月于中国海洋大学医药学院工作,2020年10月加入122cc太阳集成游戏,主要从事创新多肽药物研究和多肽药物合成技术开发。作为项目负责人,主持国家自然科学基金青年科学基金项目1项,山东省自然科学基金优秀中青年科学家奖励基金项目1项,省部共建生态化工协同创新中心优秀人才基金1项,青岛市博士后应用研究项目1项,青岛市创新创业领军人才项目子课题1项。发表论文10余篇,申请国家发明专利9项,获授权3项。
►教学情况
本科生课程:
1)化学制药工艺学:32课时,约60人;
2)制药过程安全与环境评价:32课时,约60人。
►论文、专著与专利
1、发表论文
1)Zhang, C.; Wu, L.; Liu, X.; Gao, J.; Liu, S.; Wu, J.; Huang, D.; Wang, Z.; Su, X. Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.ACS Med. Chem. Lett.2021, 12, 6, 1017–1023.
2)Zhang, C.; Li, X.; Song, D.; Ling, Y.; Zhou, Y.; Yang, X.,Synthesis, aphicidal activity and conformation of novel insect kinin analogues as potential eco-friendly insecticides.Pest Manage. Sci,2020,76, 3432-3439.
3)X. Lu, L. Wu, X. Liu, S. Wang*,C. Zhang*, BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.Bioorg. Med. Chem. Lett. 2019,29, 244-247.
4)Su, F.; Song, Q.;Zhang, C.; Xu, X.; Li, M.; Yao, D.; Wu, L.; Qu, X.; Guan, H.; Yu, G., A β-1, 3/1, 6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator.Carbohydr. Polym.2019, 114993.
5)Zhang, C.; Liu S.; Liu X.; Gao J.; Wang S., Discovery of novel inhibitors of anti-apoptotic Bcl-2 proteins derived from Bim BH3 domain.Chin. Chem. Lett.,2017, 28(7): 1523-1527.
6)Zhang, C.; Qu, Y.; Wu, X.; Song, D.; Ling, Y.; Yang, X., Eco-Friendly Insecticide Discovery via Peptidomimetics: Design, Synthesis, and Aphicidal Activity of Novel Insect Kinin Analogues.J. Agric. Food Chem.2015,63, 4527-4532.
7)Zhang, C.; Qu, Y.; Wu, X.; Song, D.; Ling, Y.; Yang, X., Design, synthesis and aphicidal activity of N-terminal modified insect kinin analogs.Peptides2015,68, 233-238.
8)Chuanliang Zhang*, Lijuan Wu, Xiaochun Liu, Jiangming Gao, Shan Liu, Juan Wu, Xianjun Qu, Xianbin Su, Discovery of Peptide Analogues of BH3 Domain of Pro-apoptotic Proteins as Novel PTP1B Inhibitors with Antidiabetic Potency in vitro and in Vivo, Abstracts of Papers, The16th Chinese International Peptide Symposium, Hefei, Anhui, P.R. China, Sep. 25-27th,2020.
9)Zhang, C.; Qu, Y.; Wu, X.; Ling, Y.; Song, D.; Yang, X., Insect kinins mimetics: Design, synthesis, and aphicidal activity as potential bioinsecticides. Abstracts of Papers, 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14,2014, AGRO-336.(国际会议论文,SCI收录)
10)Chuan-liang Zhang,Yan-yan Qu , Xiao-qing Wu, Yun Ling, Dun-lun Song, Xi-li Liu, Xin-ling Yang Design, synthesis and bioactivity of novel insect kinin analogs. Invertebrate Neuropeptide Conference 2015, Bagan, Myanmar, Feb. 15-19,2015. (国际会议论文)
11)Chuanliang Zhang,Yanyan Qu, Xiaoqing Wu, Yun Ling, Dunlun Song, Xinling Yang, Eoo-friendly insecticide discovery via peptidomimetics: Design, synthesis and aphicidal activity of insect kinin analogs. The 13th Chinese International Peptide Symposium, Datong, Shanxi, China, June 30th- July 4th,2014,pp. 114.(国际会议论文)
12)Xie, Y.; Zhang, L.;Zhang, C.; Wu, X.; Deng, X.; Yang, X.; Tobe, S. S., Synthesis, Biological Activity, and Conformational Study of N-Methylated Allatostatin Analogues Inhibiting Juvenile Hormone Biosynthesis.J. Agric. Food Chem.2015,63, 2870-2876.
13)Xie, Y.; Zhang, L.; Wu, X. Q.;Zhang, C. L.; Yang, X. L.; Tobe, S. S., Probing the active conformation of FGLamide allatostatin analogs with N-terminal modifications using NMR spectroscopy and molecular modeling.Peptides2015,68, 214-218.
2、专利
授权专利:
1)张传亮,王树林,路晓,吴丽娟,以PTP1B为靶点的新型BH3模拟肽化合物及其制备方法和应用,2022/02/21,授权专利号:ZL201811517551.X.;
2)Chuanliang Zhang, Xianbing Su, Dingmin Huang, Zhenwei Wang,Novel BH3 Mimetic Peptide Compounds Targeting PTP1B, Preparation Method and Application Thereof,2021/05/17, Filing NO. LU500160.
3)杨新玲,张传亮,凌云,宋敦伦,汪梅子,吴小庆,一类新型昆虫激肽类似物及其应用,授权专利号:ZL201510076989.9;
4)杨新玲,张传亮,凌云,宋敦伦,刘西莉,汪梅子,吴小庆,张喆,一类昆虫激肽类似物及其应用,授权专利号: ZL201510415955.8。
申请专利:
1)张传亮,一组Tachyplesin I抗菌肽衍生物及其制备方法和应用,专利申请号:202111133737.7
2)张传亮,苏贤斌,黄鼎旻,王振炜,一类抑制PTP1B活性的新型BH3模拟肽类似物及其应用,专利申请号:202011518318.0;
3)张传亮,王树林,路晓,一类新型BH3模拟肽及其应用,专利申请号:201911153714.5.
4)张传亮,王树林,路晓,吴丽娟,柳晓春,蔡兵,管华诗,一类新型PTP1B多肽抑制剂及其制备方法和应用,专利申请号:201711313716.7;
5)王树林,张传亮,刘珊,柳晓春,高江明,蔡兵,管华诗,一类靶向Bcl-2家族抗凋亡蛋白的新型BH3类似物及其应用,申请专利号:201610987871.6。
►科研项目
1)山东省省部共建生态化工协同创新中心优秀人才基金(XTCXYX17),连续流动绿色催化多肽合成研究,经费2万元,2022/01-2024/01,主持,在研;
2)青岛科技大学高层次人才启动经费,20万元,主持,在研;
3)国家自然科学基金青年基金项目(21907086),Bcl-2家族促凋亡蛋白BH3模拟肽的合成与糖尿病相关作用靶点的确认研究,经费26万元,2020/01-2022/12,主持,在研;
4)山东省自然科学基金优秀中青年科学家奖励基金(ZR2019BH088),基于双靶点的Bcl-2家族促凋亡蛋白BH3模拟肽的设计、合成与构效关系研究,经费10万元,2019/7-2022/6,主持,在研;
5)青岛市科技发展计划(15-10-3-15-(28)-zch),海洋靶向新药筛选与创新平台建设, 2015/10-2018/10,经费100万元,子课题主持(本人负责46万元),结题;
6)青岛市博士后应用研究专项(861605040085),靶向Bcl-2多肽库的构建及应用研究,2015/10-2017/10,经费5万元,主持,结题;
7)国家自然科学基金面上项目(21772181),一些海洋吲哚生物碱的合成与其生物靶点确认研究,经费66万元,2018/01-2021/12,第3位参与,在研;